LARGE, a bioinformatics software tool that employs a Large Language Model- based approach for identifying ARGs in metagenomes. This innovative approach leverages the semantic and syntactic information encoded in metagenomic sequences to achieve high accuracy and specificity in ARG identification.By utilizing the powerful pattern recognition capabilities of large language models, LARGE aims to address the limitations of existing methods and provide a more comprehensive solution for ARG classification. Our tool demonstrates significant advantages over existing methods, as evidenced by its performance on publicly available datasets.